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GR.-iJ-ES: ENDOCRINOLOGY IN GYNECOLOGY. [New Yoke Medical Jouxnu. Structures of the ovaries with the exception of the connective tissue supporting framework are derived from the germinal epitheHum. This includes the embryonic rete ovarii, and cords of Pfliiger, the interstitial cells that crowd the stroma and surround the follicles, the granulosa cells that line the fol- buy tadacip canada licles, and finally the very ova tadacip 20 price india themselves. The early investigators of the ovary as a gland of in- ternal secretion believed that the source of the secretion resided solely in the corpus luteal cells, which in turn were thought to be exclusively mod- ified granulosa cells. Further studies revealed that before the age of puberty the internal secretory function is performed by cialis generika tadacip the interstitial cells, the existence of which had long been known. This idea then became prevalent that there are two secretions ; one produced by the interstitial cells and one by the corpus luteum, and that these two secretions possess selective functional powers. However, it has been shown that the main part of tadalafil tadacip 20 mg the corpus luteum cells, the theca lutein cells of follicle atresia and the cells of the interstitial gland found in animals, are all activating inter- stitial cells. Until comparatively recently it was generally supposed, as stated by Tandler and Gross, that the interstitial cells are derived from the con- nective tissue of the ovarian stroma, but this mystery has been solved by observations that the stroma of the ovary is actually composed chiefly of interstitial cells originally derived tadacip (generic cialis) from the germinal epithe- lium and supported by a connective tissue which acts onl)- as a supporting frame work. We must conclude, therefore, that all the cellular elements to tadacip online kaufen which the source of an internal secretion may be ascribed are interstitial in character and origin. This conclusion disposes tadacip 5mg online of tadacip 20 mg uk the theory tadacip by cipla that there exist in the ovary two separate and independently functionating endocrine organs. As a practical proof of the truth of these observations one would expect to find little or no qualitative differ- ence in the clinical results from the administration of such extracts as those respectively from the corpus luteum, the whole ovary and from the stroma. And cialis generico tadacip such in fact is the case. Early in tadacip erectalis 20 mg our experience w-e gave up corpus luteum prepara- tions in favor of those compounded from the whole ovary, not tadacip erectalis 20 mg tabletten because there was any inherent tadacip 5 mg qualita- tive difference tadacip price in india in their action, but because we found that for the various gynecological purposes to which we applied them the products generika-apotheke tadacip of the whole ovary were more reliable and more intensive than those from the corpus luteum alone. In order to test the actual value of the corpus luteum we ex- cluded it altogether and treated a large number of patients with preparations from the rest of the ovary. It was not difficult to obtain the material, for up to this time it had been discarded, so far as medicinal purposes were concerned, during the manufacture of corpus luteum preparations, hence the name ovarian residue. It was no surprise to discover that the residue compared favorably with the whole ovary products, and that in some respects it appeared to be superior. Though our buy cheap tadacip observations and deductions lead us to deny the existence of two independent secretory organs in the ovary, we must admit the possibility of a minor selective action on the part of different portions of the ovarian secreting substance but even here the variation is probably a quantitative one. Thus in our cases we have found the whole extract and the residue more efficacious than the corpus luteum in treating hot tadacip pille 20mg cialis generika flushes, but the superiority is one of degree rather than one of kind. Other observers have found corpus luteum preparations of especial value in the nausea and vomiting of pregnancy. The finer distinctions drawn by some in the treatment of certain menstrual irregularities do not seem buy tadacip uk to us to have been unequivocally proved. In the light of theoietical, experimental, and anatomical knowledge combined with long con- tinued observations, our general estimate of the tadacip 20mg generic cialis ovary as a gland of internal secretion may be briefly summarized as follows. 1. For complete somatic growth and sexual de- velopment the normal secretion of the ovary is es- sential. To what extent the action of the secretion is direct, and how far it serves as a balance to other more powerful secretory influences is a matter of speculation. 2. During menstrual life and especially during the years of adolescence, the proper functioning of the ovaries has a very important bearing on the

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